TY - JOUR
T1 - The role of cocrystals in pharmaceutical science
AU - Shan, Ning
AU - Zaworotko, Michael J.
PY - 2008/5
Y1 - 2008/5
N2 - Pharmaceutical cocrystals, a subset of a long known but little-studied class of compounds, represent an emerging class of crystal forms in the context of pharmaceutical science. They are attractive to pharmaceutical scientists because they can significantly diversify the number of crystal forms that exist for a particular active pharmaceutical ingredient (API), and they can lead to improvements in physical properties of clinical relevance. In this article we address pharmaceutical cocrystals from the perspective of design (crystal engineering) and present a series of case studies that demonstrate how they can enhance the solubility, bioavailability, and/or stability of API crystal forms.
AB - Pharmaceutical cocrystals, a subset of a long known but little-studied class of compounds, represent an emerging class of crystal forms in the context of pharmaceutical science. They are attractive to pharmaceutical scientists because they can significantly diversify the number of crystal forms that exist for a particular active pharmaceutical ingredient (API), and they can lead to improvements in physical properties of clinical relevance. In this article we address pharmaceutical cocrystals from the perspective of design (crystal engineering) and present a series of case studies that demonstrate how they can enhance the solubility, bioavailability, and/or stability of API crystal forms.
UR - http://www.scopus.com/inward/record.url?scp=43049170351&partnerID=8YFLogxK
U2 - 10.1016/j.drudis.2008.03.004
DO - 10.1016/j.drudis.2008.03.004
M3 - Review article
C2 - 18468562
AN - SCOPUS:43049170351
SN - 1359-6446
VL - 13
SP - 440
EP - 446
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 9-10
ER -