TY - JOUR
T1 - The role of N-acetylcysteine in the prevention of contrast-induced nephropathy in patients undergoing peripheral angiography
T2 - A structured review and meta-analysis
AU - O'Sullivan, S.
AU - Healy, D. A.
AU - Moloney, Mary Clarke
AU - Grace, P. A.
AU - Walsh, S. R.
PY - 2013/11
Y1 - 2013/11
N2 - Contrast-induced nephropathy (CIN) is a leading cause of hospital-acquired acute kidney injury (AKI). N-acetylcysteine (NAC) was proposed as an effective preventative measure. As data in relation to the use of NAC for the prevention of CIN in peripheral angiography are lacking, a systematic review and meta-analysis were undertaken. A comprehensive search for the published and unpublished data was performed. Data were extracted from the eligible studies. Pooled odds ratios (ORs) were used to calculate the effect of NAC on CIN incidence. Pooled effect size estimates were used to calculate the effect of NAC on serum creatinine (SCr) postcontrast. Our results showed that NAC did not reduce CIN incidence (pooled OR 1.05; 95% confidence interval [CI] 0.38-2.88; P =.92) or the mean SCr levels (pooled weighted mean difference, 4.38; 95% CI 10.4-1.65; P =.15). In conclusion, insufficient evidence exists to recommend NAC for the prevention of CIN in patients undergoing peripheral angiography.
AB - Contrast-induced nephropathy (CIN) is a leading cause of hospital-acquired acute kidney injury (AKI). N-acetylcysteine (NAC) was proposed as an effective preventative measure. As data in relation to the use of NAC for the prevention of CIN in peripheral angiography are lacking, a systematic review and meta-analysis were undertaken. A comprehensive search for the published and unpublished data was performed. Data were extracted from the eligible studies. Pooled odds ratios (ORs) were used to calculate the effect of NAC on CIN incidence. Pooled effect size estimates were used to calculate the effect of NAC on serum creatinine (SCr) postcontrast. Our results showed that NAC did not reduce CIN incidence (pooled OR 1.05; 95% confidence interval [CI] 0.38-2.88; P =.92) or the mean SCr levels (pooled weighted mean difference, 4.38; 95% CI 10.4-1.65; P =.15). In conclusion, insufficient evidence exists to recommend NAC for the prevention of CIN in patients undergoing peripheral angiography.
KW - angiography
KW - contrast-induced nephropathy
KW - N-acetylcysteine
KW - peripheral angiography
KW - renal impairment
UR - http://www.scopus.com/inward/record.url?scp=84885044498&partnerID=8YFLogxK
U2 - 10.1177/0003319712467223
DO - 10.1177/0003319712467223
M3 - Review article
C2 - 23188834
AN - SCOPUS:84885044498
SN - 0003-3197
VL - 64
SP - 576
EP - 582
JO - Angiology
JF - Angiology
IS - 8
ER -