The role of N-acetylcysteine in the prevention of contrast-induced nephropathy in patients undergoing peripheral angiography: A structured review and meta-analysis

S. O'Sullivan, D. A. Healy, Mary Clarke Moloney, P. A. Grace, S. R. Walsh

Research output: Contribution to journalReview articlepeer-review

Abstract

Contrast-induced nephropathy (CIN) is a leading cause of hospital-acquired acute kidney injury (AKI). N-acetylcysteine (NAC) was proposed as an effective preventative measure. As data in relation to the use of NAC for the prevention of CIN in peripheral angiography are lacking, a systematic review and meta-analysis were undertaken. A comprehensive search for the published and unpublished data was performed. Data were extracted from the eligible studies. Pooled odds ratios (ORs) were used to calculate the effect of NAC on CIN incidence. Pooled effect size estimates were used to calculate the effect of NAC on serum creatinine (SCr) postcontrast. Our results showed that NAC did not reduce CIN incidence (pooled OR 1.05; 95% confidence interval [CI] 0.38-2.88; P =.92) or the mean SCr levels (pooled weighted mean difference, 4.38; 95% CI 10.4-1.65; P =.15). In conclusion, insufficient evidence exists to recommend NAC for the prevention of CIN in patients undergoing peripheral angiography.

Original languageEnglish
Pages (from-to)576-582
Number of pages7
JournalAngiology
Volume64
Issue number8
DOIs
Publication statusPublished - Nov 2013
Externally publishedYes

Keywords

  • angiography
  • contrast-induced nephropathy
  • N-acetylcysteine
  • peripheral angiography
  • renal impairment

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