TY - JOUR
T1 - The scientific evidence for the role of milk protein-derived bioactive peptides in humans
T2 - A Review
AU - Nongonierma, Alice B.
AU - FitzGerald, Richard J.
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Milk proteins are a good source of bioactive peptides (BAPs). BAPs can positively affect various health biomarkers in vitro. The role of milk protein-derived BAPs in humans was reviewed herein. To date, a limited number of BAPs have been identified in the gastrointestinal tract of humans and in the circulation at concentrations which may be sufficient to mediate in vivo bioactivity. While the outcomes of several human intervention studies have shown promising results, some studies have failed to demonstrate additional health benefits. This may be related to a low potency and bioavailability of the BAPs evaluated as well as confounding factors (i.e. genotype, health status and other sources of inter-individual variability). Universal guidelines for the evaluation of BAPs in humans such as adequately powered double-blind randomised clinical trials are needed.
AB - Milk proteins are a good source of bioactive peptides (BAPs). BAPs can positively affect various health biomarkers in vitro. The role of milk protein-derived BAPs in humans was reviewed herein. To date, a limited number of BAPs have been identified in the gastrointestinal tract of humans and in the circulation at concentrations which may be sufficient to mediate in vivo bioactivity. While the outcomes of several human intervention studies have shown promising results, some studies have failed to demonstrate additional health benefits. This may be related to a low potency and bioavailability of the BAPs evaluated as well as confounding factors (i.e. genotype, health status and other sources of inter-individual variability). Universal guidelines for the evaluation of BAPs in humans such as adequately powered double-blind randomised clinical trials are needed.
KW - Bioactive peptides
KW - Bioavailability
KW - Human studies
KW - Milk
UR - http://www.scopus.com/inward/record.url?scp=84938833523&partnerID=8YFLogxK
U2 - 10.1016/j.jff.2015.06.021
DO - 10.1016/j.jff.2015.06.021
M3 - Review article
AN - SCOPUS:84938833523
SN - 1756-4646
VL - 17
SP - 640
EP - 656
JO - Journal of Functional Foods
JF - Journal of Functional Foods
ER -