The structure of the hyponitrite species in a heme Fe-Cu binuclear center

Constantinos Varotsis; Takehiro Ohta; Teizo Kitagawa; Tewfik Soulimane; Eftychia Pinakoulaki

doi:10.1002/anie.200602963

The structure of the hyponitrite species in a heme Fe-Cu binuclear center

Constantinos Varotsis
, Takehiro Ohta
, Teizo Kitagawa
, Tewfik Soulimane
, Eftychia Pinakoulaki

University of Crete
National Institutes of Natural Sciences - Okazaki Institute for Integrative Bioscience
Stanford University
University of Cyprus

Research output: Contribution to journal › Article › peer-review

Abstract

NO laughing matter: The enzymatic production of laughing gas (N ₂O) from two molecules of NO requires the formation of the N-N bond and the subsequent cleavage of the N-OH bond. Resonance Raman spectroscopic studies have now provided evidence for the formation of the key intermediate, the hyponitrite species (see the optimized molecular structure), in the heme a₃ Fe-Cu_B binuclear center of ba₃- oxidoreductase from Thermus thermophilus. (Figure Presented).

Original language	English
Pages (from-to)	2210-2214
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	13
DOIs	https://doi.org/10.1002/anie.200602963
Publication status	Published - 2007

Keywords

Enzymes
Metalloenzymes
Nitrogen oxides
Raman spectroscopy
Structure elucidation

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10.1002/anie.200602963

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title = "The structure of the hyponitrite species in a heme Fe-Cu binuclear center",

abstract = "NO laughing matter: The enzymatic production of laughing gas (N 2O) from two molecules of NO requires the formation of the N-N bond and the subsequent cleavage of the N-OH bond. Resonance Raman spectroscopic studies have now provided evidence for the formation of the key intermediate, the hyponitrite species (see the optimized molecular structure), in the heme a3 Fe-CuB binuclear center of ba3- oxidoreductase from Thermus thermophilus. (Figure Presented).",

keywords = "Enzymes, Metalloenzymes, Nitrogen oxides, Raman spectroscopy, Structure elucidation",

author = "Constantinos Varotsis and Takehiro Ohta and Teizo Kitagawa and Tewfik Soulimane and Eftychia Pinakoulaki",

year = "2007",

doi = "10.1002/anie.200602963",

language = "English",

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T1 - The structure of the hyponitrite species in a heme Fe-Cu binuclear center

AU - Varotsis, Constantinos

AU - Ohta, Takehiro

AU - Kitagawa, Teizo

AU - Soulimane, Tewfik

AU - Pinakoulaki, Eftychia

PY - 2007

Y1 - 2007

N2 - NO laughing matter: The enzymatic production of laughing gas (N 2O) from two molecules of NO requires the formation of the N-N bond and the subsequent cleavage of the N-OH bond. Resonance Raman spectroscopic studies have now provided evidence for the formation of the key intermediate, the hyponitrite species (see the optimized molecular structure), in the heme a3 Fe-CuB binuclear center of ba3- oxidoreductase from Thermus thermophilus. (Figure Presented).

AB - NO laughing matter: The enzymatic production of laughing gas (N 2O) from two molecules of NO requires the formation of the N-N bond and the subsequent cleavage of the N-OH bond. Resonance Raman spectroscopic studies have now provided evidence for the formation of the key intermediate, the hyponitrite species (see the optimized molecular structure), in the heme a3 Fe-CuB binuclear center of ba3- oxidoreductase from Thermus thermophilus. (Figure Presented).

KW - Enzymes

KW - Metalloenzymes

KW - Nitrogen oxides

KW - Raman spectroscopy

KW - Structure elucidation

UR - https://www.scopus.com/pages/publications/34250374882

U2 - 10.1002/anie.200602963

DO - 10.1002/anie.200602963

M3 - Article

C2 - 17295369

AN - SCOPUS:34250374882

SN - 1433-7851

VL - 46

SP - 2210

EP - 2214

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 13

ER -

The structure of the hyponitrite species in a heme Fe-Cu binuclear center

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Keywords

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