The survival and colonic adhesion of Bifidobacterium longum infantis in patients with ulcerative colitis

Colum Dunne, Atte Von Wright, Terttu Vilpponen-Salmela, Marta Pagès Llopis, Kevin Collins, Barry Kiely, Fergus Shanahan

Research output: Contribution to journalArticlepeer-review

Abstract

While evidence of the beneficial effects of probiotics on acute intestinal disorders has been accumulating during recent years, there have been few studies on the use of probiotics in chronic diseases of the digestive tract. Since colonisation of the gut and adhesion to the intestinal mucosa have been considered as essential in probiotic action, a study with a prospective probiotic strain, Bifidobacterium infantis UCC35624, was performed with seven volunteer ulcerative colitis patients. The volunteers consumed a fermented milk product containing the strain for 5-7 days before colonoscopy. Faecal analysis demonstrated that the strain had established itself in the colon, reaching levels of 105-108 cfu g-1, depending on the individual. The strain could also be recovered from biopsies (especially from those specimens obtained from the transverse and descending part of the colon). The study provides preliminary data which support the necessity for an actual therapy trial.

Original languageEnglish (Ireland)
Pages (from-to)197-200
Number of pages4
JournalInternational Dairy Journal
Volume12
Issue number2-3
DOIs
Publication statusPublished - 2002

Keywords

  • Adhesion
  • Colonisation
  • Probiotic bacteria
  • Ulcerative colitis

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