Tibolone as Hormonal Therapy and Neuroprotective Agent

Juan Pablo Del Río; Santiago Molina; Oscar Hidalgo-Lanussa; Luis Miguel Garcia-Segura; George E. Barreto

doi:10.1016/j.tem.2020.04.007

Tibolone as Hormonal Therapy and Neuroprotective Agent

Juan Pablo Del Río, Santiago Molina, Oscar Hidalgo-Lanussa, Luis Miguel Garcia-Segura, George E. Barreto

Department of Biological Sciences

Research output: Contribution to journal › Review article › peer-review

Abstract

Tibolone (TIB), a selective tissue estrogenic activity regulator (STEAR) in clinical use by postmenopausal women, activates hormonal receptors in a tissue-specific manner. Estrogenic activity is present mostly in the brain, vagina, and bone, while the inactive forms predominate in the endometrium and breast. Conflicting literature on TIB's actions has been observed. While it has benefits for vasomotor symptoms, bone demineralization, and sexual health, a higher relative risk of hormone-sensitive cancer has been reported. In the brain, TIB can improve mood and cognition, neuroinflammation, and reactive gliosis. This review aims to discuss the systemic effects of TIB on peri- and post-menopausal women and its role in the brain. We suggest that TIB is a hormonal therapy with promising neuroprotective properties.

Original language	English
Pages (from-to)	742-759
Number of pages	18
Journal	Trends in Endocrinology and Metabolism
Volume	31
Issue number	10
DOIs	https://doi.org/10.1016/j.tem.2020.04.007
Publication status	Published - Oct 2020

Keywords

breast
central nervous system
hormonal therapy
neuroprotection
tibolone
uterus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tem.2020.04.007

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title = "Tibolone as Hormonal Therapy and Neuroprotective Agent",

abstract = "Tibolone (TIB), a selective tissue estrogenic activity regulator (STEAR) in clinical use by postmenopausal women, activates hormonal receptors in a tissue-specific manner. Estrogenic activity is present mostly in the brain, vagina, and bone, while the inactive forms predominate in the endometrium and breast. Conflicting literature on TIB's actions has been observed. While it has benefits for vasomotor symptoms, bone demineralization, and sexual health, a higher relative risk of hormone-sensitive cancer has been reported. In the brain, TIB can improve mood and cognition, neuroinflammation, and reactive gliosis. This review aims to discuss the systemic effects of TIB on peri- and post-menopausal women and its role in the brain. We suggest that TIB is a hormonal therapy with promising neuroprotective properties.",

keywords = "breast, central nervous system, hormonal therapy, neuroprotection, tibolone, uterus",

author = "{Del R{\'i}o}, {Juan Pablo} and Santiago Molina and Oscar Hidalgo-Lanussa and Garcia-Segura, {Luis Miguel} and Barreto, {George E.}",

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doi = "10.1016/j.tem.2020.04.007",

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T1 - Tibolone as Hormonal Therapy and Neuroprotective Agent

AU - Del Río, Juan Pablo

AU - Molina, Santiago

AU - Hidalgo-Lanussa, Oscar

AU - Garcia-Segura, Luis Miguel

AU - Barreto, George E.

PY - 2020/10

Y1 - 2020/10

N2 - Tibolone (TIB), a selective tissue estrogenic activity regulator (STEAR) in clinical use by postmenopausal women, activates hormonal receptors in a tissue-specific manner. Estrogenic activity is present mostly in the brain, vagina, and bone, while the inactive forms predominate in the endometrium and breast. Conflicting literature on TIB's actions has been observed. While it has benefits for vasomotor symptoms, bone demineralization, and sexual health, a higher relative risk of hormone-sensitive cancer has been reported. In the brain, TIB can improve mood and cognition, neuroinflammation, and reactive gliosis. This review aims to discuss the systemic effects of TIB on peri- and post-menopausal women and its role in the brain. We suggest that TIB is a hormonal therapy with promising neuroprotective properties.

AB - Tibolone (TIB), a selective tissue estrogenic activity regulator (STEAR) in clinical use by postmenopausal women, activates hormonal receptors in a tissue-specific manner. Estrogenic activity is present mostly in the brain, vagina, and bone, while the inactive forms predominate in the endometrium and breast. Conflicting literature on TIB's actions has been observed. While it has benefits for vasomotor symptoms, bone demineralization, and sexual health, a higher relative risk of hormone-sensitive cancer has been reported. In the brain, TIB can improve mood and cognition, neuroinflammation, and reactive gliosis. This review aims to discuss the systemic effects of TIB on peri- and post-menopausal women and its role in the brain. We suggest that TIB is a hormonal therapy with promising neuroprotective properties.

KW - breast

KW - central nervous system

KW - hormonal therapy

KW - neuroprotection

KW - tibolone

KW - uterus

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ER -

Tibolone as Hormonal Therapy and Neuroprotective Agent

Abstract

Keywords

UN SDGs

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