Towards the development of an in vitro model of atherosclerotic peripheral vessels for evaluating drug-coated endovascular technologies

Research output: Contribution to journalReview articlepeer-review

Abstract

Here, we review the in vitro models used to evaluate drug-coated endovascular technologies. The models are assessed in the context of representing the drug transport/uptake and mechanical properties of atherosclerotic peripheral vessels. Studies to date have incorporated a vessel-simulating hydrogel compartment to examine drug elution from endovascular devices. However, comparisons between in vitro models and atherosclerotic tissue are difficult because ex vivo data are limited in their applicability to diseased peripheral vessels. Furthermore, appropriate ex vivo mechanical properties are not incorporated into these models. Therefore, there is a need to characterise the drug transport/uptake properties of appropriate atherosclerotic tissue and incorporate existing ex vivo mechanical data into current in vitro models to more accurately represent drug behaviour in atherosclerotic peripheral vessels.

Original languageEnglish
Pages (from-to)1512-1520
Number of pages9
JournalDrug Discovery Today
Volume21
Issue number9
DOIs
Publication statusPublished - 1 Sep 2016

Fingerprint

Dive into the research topics of 'Towards the development of an in vitro model of atherosclerotic peripheral vessels for evaluating drug-coated endovascular technologies'. Together they form a unique fingerprint.

Cite this