TY - JOUR
T1 - Towards the development of an in vitro model of atherosclerotic peripheral vessels for evaluating drug-coated endovascular technologies
AU - Cunnane, Eoghan M.
AU - Walsh, Michael T.
N1 - Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Here, we review the in vitro models used to evaluate drug-coated endovascular technologies. The models are assessed in the context of representing the drug transport/uptake and mechanical properties of atherosclerotic peripheral vessels. Studies to date have incorporated a vessel-simulating hydrogel compartment to examine drug elution from endovascular devices. However, comparisons between in vitro models and atherosclerotic tissue are difficult because ex vivo data are limited in their applicability to diseased peripheral vessels. Furthermore, appropriate ex vivo mechanical properties are not incorporated into these models. Therefore, there is a need to characterise the drug transport/uptake properties of appropriate atherosclerotic tissue and incorporate existing ex vivo mechanical data into current in vitro models to more accurately represent drug behaviour in atherosclerotic peripheral vessels.
AB - Here, we review the in vitro models used to evaluate drug-coated endovascular technologies. The models are assessed in the context of representing the drug transport/uptake and mechanical properties of atherosclerotic peripheral vessels. Studies to date have incorporated a vessel-simulating hydrogel compartment to examine drug elution from endovascular devices. However, comparisons between in vitro models and atherosclerotic tissue are difficult because ex vivo data are limited in their applicability to diseased peripheral vessels. Furthermore, appropriate ex vivo mechanical properties are not incorporated into these models. Therefore, there is a need to characterise the drug transport/uptake properties of appropriate atherosclerotic tissue and incorporate existing ex vivo mechanical data into current in vitro models to more accurately represent drug behaviour in atherosclerotic peripheral vessels.
UR - http://www.scopus.com/inward/record.url?scp=84977483525&partnerID=8YFLogxK
U2 - 10.1016/j.drudis.2016.05.019
DO - 10.1016/j.drudis.2016.05.019
M3 - Review article
C2 - 27297733
AN - SCOPUS:84977483525
SN - 1359-6446
VL - 21
SP - 1512
EP - 1520
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 9
ER -