TY - JOUR
T1 - Transition Metal Coordination Complexes of Flavonoids
T2 - A Class of Better Pharmacological Active Molecules to Develop New Drugs
AU - Jayaprakash, Sushmitha
AU - Ramesh, Sruthi
AU - Karthikeyan, Aishwarya
AU - Murugappan, Sivasubramanian
AU - Sidharthan, Priyadharshini
AU - Selvaraj, Stalin
N1 - Publisher Copyright:
© 2023 Bentham Science Publishers.
PY - 2023/2
Y1 - 2023/2
N2 - Flavonoid metal ion complexes are one of the classes of biologically active molecules with immense pharmacological potential, including antioxidant, antidiabetic, antimicrobial, and anticancer activity, to name a few. The effectiveness of this complexion depends on the state and nature of the transition metal ions and on the position to which the metal ion coordinates with their corresponding parent flavonoid. The metal coordination of flavonoids also improves the biological activities to a maximum extent compared to the parent compound. This may be attributed to many factors such as metal ions, coordination sites, structural configuration, and stability of the complexes. On the other hand, some of the metal ion complexes reduce the biological efficiency of the corresponding parent flavonoids, which can be due to the shift from antioxidant to pro-oxidant nature as well as the stability of the complexes both in in vitro and in vivo conditions. However, the literature on the stability of flavonoid metal ion complexes in in vivo conditions is very scanty. Therefore, this review summarizes and critically addresses all these parameters a favor together in a single slot that favours for the researchers to put forward to understand the mode and detailed molecular mechanism of flavonoid metals complexes compared with their corresponding parent flavonoids.
AB - Flavonoid metal ion complexes are one of the classes of biologically active molecules with immense pharmacological potential, including antioxidant, antidiabetic, antimicrobial, and anticancer activity, to name a few. The effectiveness of this complexion depends on the state and nature of the transition metal ions and on the position to which the metal ion coordinates with their corresponding parent flavonoid. The metal coordination of flavonoids also improves the biological activities to a maximum extent compared to the parent compound. This may be attributed to many factors such as metal ions, coordination sites, structural configuration, and stability of the complexes. On the other hand, some of the metal ion complexes reduce the biological efficiency of the corresponding parent flavonoids, which can be due to the shift from antioxidant to pro-oxidant nature as well as the stability of the complexes both in in vitro and in vivo conditions. However, the literature on the stability of flavonoid metal ion complexes in in vivo conditions is very scanty. Therefore, this review summarizes and critically addresses all these parameters a favor together in a single slot that favours for the researchers to put forward to understand the mode and detailed molecular mechanism of flavonoid metals complexes compared with their corresponding parent flavonoids.
KW - anticancer
KW - antidiabetic
KW - antimicrobial
KW - Antioxidant
KW - biological activity
KW - flavonoids
KW - metal complexes
KW - parent flavonoid
UR - http://www.scopus.com/inward/record.url?scp=85147218415&partnerID=8YFLogxK
U2 - 10.2174/1871520622666220520093018
DO - 10.2174/1871520622666220520093018
M3 - Review article
C2 - 35619308
AN - SCOPUS:85147218415
SN - 1871-5206
VL - 23
SP - 417
EP - 431
JO - Anti-Cancer Agents in Medicinal Chemistry
JF - Anti-Cancer Agents in Medicinal Chemistry
IS - 4
ER -