TY - JOUR
T1 - Triglyceride glucose index and carotid atherosclerosis incidence in the Chinese population
T2 - A prospective cohort study
AU - Wu, Zhiyuan
AU - Wang, Jinqi
AU - Li, Zhiwei
AU - Han, Ze
AU - Miao, Xinlei
AU - Liu, Xiangtong
AU - Li, Xia
AU - Wang, Wei
AU - Guo, Xiuhua
AU - Tao, Lixin
N1 - Publisher Copyright:
© 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University
PY - 2021/6/30
Y1 - 2021/6/30
N2 - Background and aims: The association of the triglyceride glucose (TyG) index with carotid atherosclerosis has not been reported in longitudinal studies. The present study aimed to investigate whether the TyG index increases the risk of carotid atherosclerosis incidence. Methods and results: This study included data from the Beijing Health Management Cohort (BHMC; n = 6955) and the Beijing Physical Examination Cohort (BPEC; n = 8473). Participants without a history of carotid atherosclerosis who underwent health examination in 2011 or 2012 were annually followed until 2019. The TyG index was denoted as ln [triglycerides (mmol/L)∗fasting glucose (mmol/L)/2]. During a median follow-up of 5.02 years and 5.36 years, 1441 individuals in the BHMC group and 2181 individuals in the BPEC group developed carotid plaque, respectively. The adjusted hazard ratios (HRs) of the continuous TyG index were 1.253 (95% CI, 1.044 to 1.505) and 1.252 (95% CI, 1.091 to 1.437) for the BHMC and BPEC groups, respectively. Individuals in the highest quartile of the TyG index were associated with an increased risk of carotid plaque compared with those in the lowest quartile (BHMC: HR, 1.366; 95% CI, 1.101 to 1.695, P for trend = 0.010; BPEC: HR, 1.379; 95% CI, 1.196 to 1.591, P for trend = 0.013). Conclusion: These findings suggested that a higher TyG index increases the risk of carotid atherosclerosis incidence in the general population.
AB - Background and aims: The association of the triglyceride glucose (TyG) index with carotid atherosclerosis has not been reported in longitudinal studies. The present study aimed to investigate whether the TyG index increases the risk of carotid atherosclerosis incidence. Methods and results: This study included data from the Beijing Health Management Cohort (BHMC; n = 6955) and the Beijing Physical Examination Cohort (BPEC; n = 8473). Participants without a history of carotid atherosclerosis who underwent health examination in 2011 or 2012 were annually followed until 2019. The TyG index was denoted as ln [triglycerides (mmol/L)∗fasting glucose (mmol/L)/2]. During a median follow-up of 5.02 years and 5.36 years, 1441 individuals in the BHMC group and 2181 individuals in the BPEC group developed carotid plaque, respectively. The adjusted hazard ratios (HRs) of the continuous TyG index were 1.253 (95% CI, 1.044 to 1.505) and 1.252 (95% CI, 1.091 to 1.437) for the BHMC and BPEC groups, respectively. Individuals in the highest quartile of the TyG index were associated with an increased risk of carotid plaque compared with those in the lowest quartile (BHMC: HR, 1.366; 95% CI, 1.101 to 1.695, P for trend = 0.010; BPEC: HR, 1.379; 95% CI, 1.196 to 1.591, P for trend = 0.013). Conclusion: These findings suggested that a higher TyG index increases the risk of carotid atherosclerosis incidence in the general population.
KW - Carotid atherosclerosis
KW - Carotid plaque
KW - Cohort study
KW - Insulin resistance
KW - Triglyceride glucose index
UR - http://www.scopus.com/inward/record.url?scp=85106480033&partnerID=8YFLogxK
U2 - 10.1016/j.numecd.2021.03.027
DO - 10.1016/j.numecd.2021.03.027
M3 - Article
C2 - 34045133
AN - SCOPUS:85106480033
SN - 0939-4753
VL - 31
SP - 2042
EP - 2050
JO - Nutrition, Metabolism and Cardiovascular Diseases
JF - Nutrition, Metabolism and Cardiovascular Diseases
IS - 7
ER -
