Two-Dimensional Nanosized Metal-Organic Frameworks for Biosensing and Bioimaging Applications

Metal organic frameworks (MOFs), specifically, two-dimensional MOFs (2D-MOFs), have appeared as a wide-ranging crystalline material exhibiting superhigh porosity, tunable pore size and massive internal surface area. 2D-MOFs-based materials have been explored for the fabrication of sensors showing potential biosensing and bioimaging applications. Biosensing and bioimaging strategies are one of the most crucial and promising tools for achieving rapid, sensitive, and selective analysis in various clinical and biomedical fields of application. The biosensing features of MOFs are considered due to exceptional water stability, superior biodegradability, and biocompatibility with low or negligible toxicity. The MOFs can be specifically modified, physically or chemically, for detecting heavy-metals, metallic substrates, cells, and tissues in diverse sample types. In addition, the versatile characteristics of MOFs, associated with both organic and inorganic components, have made them a crucial material in clean energy, high-capacity adsorbing, and gas storing applications. Thus, MOFsbased materials can act as a potential platform exhibiting superior biosensing and bioimaging applications. Herein, we have discussed and summarized various synthesis approaches, characterization strategies, and biosensing and bioimaging applications of 2D-MOFs with their clinical significance in various biomedical applications.