TY - JOUR
T1 - Unlocking Exosome-Based Theragnostic Signatures
T2 - Deciphering Secrets of Ovarian Cancer Metastasis
AU - Mukherjee, Sayantanee
AU - Nag, Sagnik
AU - Mukerjee, Nobendu
AU - Maitra, Swastika
AU - Muthusamy, Raman
AU - Fuloria, Neeraj Kumar
AU - Fuloria, Shivkanya
AU - Adhikari, Manab Deb
AU - Anand, Krishnan
AU - Thorat, Nanasaheb
AU - Subramaniyan, Vetriselvan
AU - Gorai, Sukhamoy
N1 - Publisher Copyright:
© 2023 The Authors. Published by American Chemical Society.
PY - 2023/10/10
Y1 - 2023/10/10
N2 - Ovarian cancer (OC) is a common gynecological cancer worldwide. Unfortunately, the lack of early detection methods translates into a substantial cohort of women grappling with the pressing health crisis. The discovery of extracellular vesicles (EVs) (their major subpopulation exosomes, microvesicles, and apoptotic bodies) has provided new insights into the understanding of cancer. Exosomes, a subpopulation of EVs, play a crucial role in cellular communication and reflect the cellular status under both healthy and pathological conditions. Tumor-derived exosomes (TEXs) dynamically influence ovarian cancer progression by regulating uncontrolled cell growth, immune suppression, angiogenesis, metastasis, and the development of drug and therapeutic resistance. In the field of OC diagnostics, TEXs offer potential biomarkers in various body fluids. On the other hand, exosomes have also shown promising abilities to cure ovarian cancer. In this review, we address the interlink between exosomes and ovarian cancer and explore their theragnostic signature. Finally, we highlight future directions of exosome-based ovarian cancer research.
AB - Ovarian cancer (OC) is a common gynecological cancer worldwide. Unfortunately, the lack of early detection methods translates into a substantial cohort of women grappling with the pressing health crisis. The discovery of extracellular vesicles (EVs) (their major subpopulation exosomes, microvesicles, and apoptotic bodies) has provided new insights into the understanding of cancer. Exosomes, a subpopulation of EVs, play a crucial role in cellular communication and reflect the cellular status under both healthy and pathological conditions. Tumor-derived exosomes (TEXs) dynamically influence ovarian cancer progression by regulating uncontrolled cell growth, immune suppression, angiogenesis, metastasis, and the development of drug and therapeutic resistance. In the field of OC diagnostics, TEXs offer potential biomarkers in various body fluids. On the other hand, exosomes have also shown promising abilities to cure ovarian cancer. In this review, we address the interlink between exosomes and ovarian cancer and explore their theragnostic signature. Finally, we highlight future directions of exosome-based ovarian cancer research.
UR - http://www.scopus.com/inward/record.url?scp=85174974196&partnerID=8YFLogxK
U2 - 10.1021/acsomega.3c02837
DO - 10.1021/acsomega.3c02837
M3 - Review article
AN - SCOPUS:85174974196
SN - 2470-1343
VL - 8
SP - 36614
EP - 36627
JO - ACS Omega
JF - ACS Omega
IS - 40
ER -
