TY - JOUR
T1 - Unsuspected intrinsic property of melanin to dissociate water can be used for the treatment of CNS diseases
AU - Herrera, Arturo Solís
AU - Esparza, María del Carmen Arias
AU - Arias, Paola Eugenia Solís
AU - Ávila-Rodriguez, Marco
AU - Barreto, George Emilio
AU - Li, Yi
AU - Bachurin, Sergey Olegovich
AU - Aliev, Gjumrakch
N1 - Publisher Copyright:
© 2016 Bentham Science Publishers.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Retinal adhesion mechanisms in mammals are quite complex and multifactorial in nature. To date, these mechanisms are incompletely understood due to a variety of chemical, physical, and physiological forces impinging upon retinal tissue: retinal pigment epithelium, nearby tissues as sclera and vitreous, the subretinal space, and the highly complex interphotoreceptor matrix that fills subretinal space. The adhesion of the retina to the choroid, rather than anatomical, is a dynamic process, as the retina detaches a few minutes after life ceases. The adhesion mechanisms described in the literature, such as intraocular pressure and the oncotic pressure of the choroid that seems to push the retina towards the choroid, the delicate anatomical relationships between the rod and cone photoreceptors, the retinal pigment epithelium, the existence of a complex material called interphotoreceptor matrix, as well as other metabolic and structural factors, still cannot explain the remarkable features observed in the adhesion mechanisms between the photoreceptor layer and retinal pigment epithelium cells. The unexpected intrinsic property of melanin to absorb light energy and transform it into chemically based free energy can explain normal adhesion of the sensory retina to the pigment epithelium. In this article, we explore and highlight this explanation, which states that it is definitely able to provide a new treatment avenue against devastating neurodegenerative properties.
AB - Retinal adhesion mechanisms in mammals are quite complex and multifactorial in nature. To date, these mechanisms are incompletely understood due to a variety of chemical, physical, and physiological forces impinging upon retinal tissue: retinal pigment epithelium, nearby tissues as sclera and vitreous, the subretinal space, and the highly complex interphotoreceptor matrix that fills subretinal space. The adhesion of the retina to the choroid, rather than anatomical, is a dynamic process, as the retina detaches a few minutes after life ceases. The adhesion mechanisms described in the literature, such as intraocular pressure and the oncotic pressure of the choroid that seems to push the retina towards the choroid, the delicate anatomical relationships between the rod and cone photoreceptors, the retinal pigment epithelium, the existence of a complex material called interphotoreceptor matrix, as well as other metabolic and structural factors, still cannot explain the remarkable features observed in the adhesion mechanisms between the photoreceptor layer and retinal pigment epithelium cells. The unexpected intrinsic property of melanin to absorb light energy and transform it into chemically based free energy can explain normal adhesion of the sensory retina to the pigment epithelium. In this article, we explore and highlight this explanation, which states that it is definitely able to provide a new treatment avenue against devastating neurodegenerative properties.
KW - Melanin
KW - Oncotic pressure
KW - Pharmacological effects
KW - Photoreceptors
KW - QIAPI-1- (Medical enhancer of human photosynthesis or chemical energy modulator)
KW - Retina
UR - http://www.scopus.com/inward/record.url?scp=84959930600&partnerID=8YFLogxK
U2 - 10.2174/1871527315666160202122943
DO - 10.2174/1871527315666160202122943
M3 - Article
C2 - 26831264
AN - SCOPUS:84959930600
SN - 1871-5273
VL - 15
SP - 135
EP - 140
JO - CNS and Neurological Disorders - Drug Targets
JF - CNS and Neurological Disorders - Drug Targets
IS - 2
ER -