TY - JOUR
T1 - Urotensin II
T2 - Molecular mechanisms of biological activity
AU - Svistunov, Andrey A.
AU - Tarasov, Vadim V.
AU - Shakhmardanova, Svetlana A.
AU - Sologova, Susanna S.
AU - Bagaturiya, Ekaterina T.
AU - Chubarev, Vladimir N.
AU - Galenko-Yaroshevsky, Pavel A.
AU - Ávila-Rodriguez, Marco Fidel
AU - Barreto, George E.
AU - Aliev, Gjumrakch
N1 - Publisher Copyright:
© 2018 Bentham Science Publishers.
PY - 2018
Y1 - 2018
N2 - Urotensin II (UT II) is an important factor of cellular homeostasis. This regulatory peptide is involved in the pathophysiology of many disorders. For example, it plays an important role in the pathogenesis of acute and chronic diseases, stressful and adaptive reactions of the body, in the development of cardiovascular pathologies, metabolic syndrome, inflammation, liver cirrhosis, renal failure, diabetic nephropathy, reproductive dysfunction, progression of psychosomatic, psychoendocrinal and psychiatric disorders. In this concern, the involvement of UT II in the pathophysiology of many processes determines the perspectives for the development of blockers of urotensin receptors for the treatment of the aforementioned diseases. It is important that even today this kind of perspective is feasible due to the synthesis of a series of GPR14 blockers. The objective of this review is to discuss current molecular mechanisms of biological activity, regulatory functions of UT II, its role in the pathogenesis of different nosologies, as well as analysis of the possible routes of exposure to GPR14 as potential therapeutic targets.
AB - Urotensin II (UT II) is an important factor of cellular homeostasis. This regulatory peptide is involved in the pathophysiology of many disorders. For example, it plays an important role in the pathogenesis of acute and chronic diseases, stressful and adaptive reactions of the body, in the development of cardiovascular pathologies, metabolic syndrome, inflammation, liver cirrhosis, renal failure, diabetic nephropathy, reproductive dysfunction, progression of psychosomatic, psychoendocrinal and psychiatric disorders. In this concern, the involvement of UT II in the pathophysiology of many processes determines the perspectives for the development of blockers of urotensin receptors for the treatment of the aforementioned diseases. It is important that even today this kind of perspective is feasible due to the synthesis of a series of GPR14 blockers. The objective of this review is to discuss current molecular mechanisms of biological activity, regulatory functions of UT II, its role in the pathogenesis of different nosologies, as well as analysis of the possible routes of exposure to GPR14 as potential therapeutic targets.
KW - Cancer
KW - Drug design
KW - G-protein-coupled receptors
KW - Hormonal systems
KW - Kidney
KW - Molecular targets of Urotensin II in cardiovascular
KW - Nervous
KW - Regulatory peptides
KW - Sexual function
KW - Stress
KW - Urotensin II
UR - http://www.scopus.com/inward/record.url?scp=85051422457&partnerID=8YFLogxK
U2 - 10.2174/1389203718666170829162335
DO - 10.2174/1389203718666170829162335
M3 - Review article
C2 - 28875851
AN - SCOPUS:85051422457
SN - 1389-2037
VL - 19
SP - 924
EP - 934
JO - Current Protein and Peptide Science
JF - Current Protein and Peptide Science
IS - 9
ER -
