Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection

Elizabeth J. Ryan; Megan Dring; Cliona M. Ryan; Carol McNulty; Nigel J. Stevenson; Matthew W. Lawless; John Crowe; Niamh Nolan; John E. Hegarty; Cliona O'Farrelly

doi:10.1016/j.humimm.2010.05.007

Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection

Elizabeth J. Ryan, Megan Dring, Cliona M. Ryan, Carol McNulty, Nigel J. Stevenson, Matthew W. Lawless, John Crowe, Niamh Nolan, John E. Hegarty, Cliona O'Farrelly

Research output: Contribution to journal › Article › peer-review

Abstract

CD209, a c-type lectin expressed by dendritic cells (DCs), acts as a pathogen recognition receptor. A single nucleotide polymorphism (SNP) in the promoter region of CD209 (-336 A/G; rs4804803) affects transcription and is associated with the severity of tuberculosis and dengue fever. Because CD209 binds hepatitis C virus (HCV) glycoprotein-E2, we investigated this SNP in the context of chronic HCV infection. A total of 131 Irish women who had received HCV-contaminated anti-D-immunoglobulin and 79 healthy control subjects were genotyped. We found no association between rs4804803 and the risk of HCV chronicity. However, of those with chronic infection, possession of at least one g-allele was associated with more advanced liver disease, with significantly higher liver fibrosis scores and levels of alanine transaminase (ALT) observed. We conclude that rs4804803, an SNP in the CD209 promoter, contributes to severity of liver disease in chronic HCV infection.

Original language	English
Pages (from-to)	829-832
Number of pages	4
Journal	Human Immunology
Volume	71
Issue number	8
DOIs	https://doi.org/10.1016/j.humimm.2010.05.007
Publication status	Published - Aug 2010
Externally published	Yes

Keywords

CD209
Chronic viral infection
DC-SIGN
Hepatitis C virus
Single-nucleotide polymorphism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.humimm.2010.05.007

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title = "Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection",

abstract = "CD209, a c-type lectin expressed by dendritic cells (DCs), acts as a pathogen recognition receptor. A single nucleotide polymorphism (SNP) in the promoter region of CD209 (-336 A/G; rs4804803) affects transcription and is associated with the severity of tuberculosis and dengue fever. Because CD209 binds hepatitis C virus (HCV) glycoprotein-E2, we investigated this SNP in the context of chronic HCV infection. A total of 131 Irish women who had received HCV-contaminated anti-D-immunoglobulin and 79 healthy control subjects were genotyped. We found no association between rs4804803 and the risk of HCV chronicity. However, of those with chronic infection, possession of at least one g-allele was associated with more advanced liver disease, with significantly higher liver fibrosis scores and levels of alanine transaminase (ALT) observed. We conclude that rs4804803, an SNP in the CD209 promoter, contributes to severity of liver disease in chronic HCV infection.",

keywords = "CD209, Chronic viral infection, DC-SIGN, Hepatitis C virus, Single-nucleotide polymorphism",

author = "Ryan, {Elizabeth J.} and Megan Dring and Ryan, {Cliona M.} and Carol McNulty and Stevenson, {Nigel J.} and Lawless, {Matthew W.} and John Crowe and Niamh Nolan and Hegarty, {John E.} and Cliona O'Farrelly",

year = "2010",

month = aug,

doi = "10.1016/j.humimm.2010.05.007",

language = "English",

volume = "71",

pages = "829--832",

journal = "Human Immunology",

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T1 - Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection

AU - Ryan, Elizabeth J.

AU - Dring, Megan

AU - Ryan, Cliona M.

AU - McNulty, Carol

AU - Stevenson, Nigel J.

AU - Lawless, Matthew W.

AU - Crowe, John

AU - Nolan, Niamh

AU - Hegarty, John E.

AU - O'Farrelly, Cliona

PY - 2010/8

Y1 - 2010/8

N2 - CD209, a c-type lectin expressed by dendritic cells (DCs), acts as a pathogen recognition receptor. A single nucleotide polymorphism (SNP) in the promoter region of CD209 (-336 A/G; rs4804803) affects transcription and is associated with the severity of tuberculosis and dengue fever. Because CD209 binds hepatitis C virus (HCV) glycoprotein-E2, we investigated this SNP in the context of chronic HCV infection. A total of 131 Irish women who had received HCV-contaminated anti-D-immunoglobulin and 79 healthy control subjects were genotyped. We found no association between rs4804803 and the risk of HCV chronicity. However, of those with chronic infection, possession of at least one g-allele was associated with more advanced liver disease, with significantly higher liver fibrosis scores and levels of alanine transaminase (ALT) observed. We conclude that rs4804803, an SNP in the CD209 promoter, contributes to severity of liver disease in chronic HCV infection.

AB - CD209, a c-type lectin expressed by dendritic cells (DCs), acts as a pathogen recognition receptor. A single nucleotide polymorphism (SNP) in the promoter region of CD209 (-336 A/G; rs4804803) affects transcription and is associated with the severity of tuberculosis and dengue fever. Because CD209 binds hepatitis C virus (HCV) glycoprotein-E2, we investigated this SNP in the context of chronic HCV infection. A total of 131 Irish women who had received HCV-contaminated anti-D-immunoglobulin and 79 healthy control subjects were genotyped. We found no association between rs4804803 and the risk of HCV chronicity. However, of those with chronic infection, possession of at least one g-allele was associated with more advanced liver disease, with significantly higher liver fibrosis scores and levels of alanine transaminase (ALT) observed. We conclude that rs4804803, an SNP in the CD209 promoter, contributes to severity of liver disease in chronic HCV infection.

KW - CD209

KW - Chronic viral infection

KW - DC-SIGN

KW - Hepatitis C virus

KW - Single-nucleotide polymorphism

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U2 - 10.1016/j.humimm.2010.05.007

DO - 10.1016/j.humimm.2010.05.007

M3 - Article

C2 - 20470843

AN - SCOPUS:77954762142

SN - 0198-8859

VL - 71

SP - 829

EP - 832

JO - Human Immunology

JF - Human Immunology

IS - 8

ER -

Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection

Abstract

Keywords

UN SDGs

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