TY - JOUR
T1 - Vascularization Approaches in Tissue Engineering
T2 - Recent Developments on Evaluation Tests and Modulation
AU - Lopes, Soraia V.
AU - Collins, Maurice N.
AU - Reis, Rui L.
AU - Oliveira, Joaquim M.
AU - Silva-Correia, Joana
N1 - Publisher Copyright:
© 2021 American Chemical Society.
PY - 2021/4/19
Y1 - 2021/4/19
N2 - This review focuses on vascularization and strategies involved in its evaluation and modulation. Clinical issues associated with engineered tissues of an atomically relevant size that require a vascular network to supply their cells with nutrients and oxygen are analyzed in terms of vascular network formation within scaffolds, which can be produced from varying biomaterials, with the capability of connecting to the vasculature of the patient. Developing angiogenesis techniques and monitoring of angiogenesis development as well as how these methods can be further utilized to tailor vascularization within large tissue engineered constructs are also discussed. Finally, we offer a glimpse toward the future by providing an outlook for vascularization and associated emerging bioprinting concepts in tissue engineering applications.
AB - This review focuses on vascularization and strategies involved in its evaluation and modulation. Clinical issues associated with engineered tissues of an atomically relevant size that require a vascular network to supply their cells with nutrients and oxygen are analyzed in terms of vascular network formation within scaffolds, which can be produced from varying biomaterials, with the capability of connecting to the vasculature of the patient. Developing angiogenesis techniques and monitoring of angiogenesis development as well as how these methods can be further utilized to tailor vascularization within large tissue engineered constructs are also discussed. Finally, we offer a glimpse toward the future by providing an outlook for vascularization and associated emerging bioprinting concepts in tissue engineering applications.
KW - angiogenesis
KW - in vitro/ in vivo assays
KW - tissue engineering
KW - tissue scaffolds
KW - vascularization
UR - http://www.scopus.com/inward/record.url?scp=85105081896&partnerID=8YFLogxK
U2 - 10.1021/acsabm.1c00051
DO - 10.1021/acsabm.1c00051
M3 - Review article
C2 - 35014385
AN - SCOPUS:85105081896
SN - 2576-6422
VL - 4
SP - 2941
EP - 2956
JO - ACS Applied Bio Materials
JF - ACS Applied Bio Materials
IS - 4
ER -