TY - JOUR
T1 - Verapamil is beneficial in a model of post-ERCP pancreatitis
AU - Leahy, Austin L.
AU - Darzi, Ara
AU - Grace, Pierce
AU - Qureshi, Akthar
AU - Redmond, Paul
AU - Leader, Mary
AU - Bouchier-Hayes, David J.
AU - Broe, Patrick
PY - 1993/6
Y1 - 1993/6
N2 - To assess the effect of the calcium blocking drug, verapamil, in an experimental model of acute pancreatitis. Acute pancreatitis was induced by retrograde taurocholate injection into the pancreato-biliary duct of Sprague-Dawley rats. The rats were then randomized into four groups and 1 ml saline or verapamil (1 g/kg) was administered before induction of pancreatitis or 2 h after taurocholate injection. Pancreatitis was confirmed by elevation of serum amylase levels and by histological alterations in pancreatic specimens from all animals. Survival was significantly increased in rats given verapamil prior to the induction of pancreatitis; however, delayed treatment was not effective. This study suggests that verapamil may have a beneficial role in the prophylaxis of pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP).
AB - To assess the effect of the calcium blocking drug, verapamil, in an experimental model of acute pancreatitis. Acute pancreatitis was induced by retrograde taurocholate injection into the pancreato-biliary duct of Sprague-Dawley rats. The rats were then randomized into four groups and 1 ml saline or verapamil (1 g/kg) was administered before induction of pancreatitis or 2 h after taurocholate injection. Pancreatitis was confirmed by elevation of serum amylase levels and by histological alterations in pancreatic specimens from all animals. Survival was significantly increased in rats given verapamil prior to the induction of pancreatitis; however, delayed treatment was not effective. This study suggests that verapamil may have a beneficial role in the prophylaxis of pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP).
KW - Acute pancreatitis
KW - Calcium blockade
KW - Endoscopic retrograde cholangiopanceatography
KW - Verapamil
UR - http://www.scopus.com/inward/record.url?scp=0027163919&partnerID=8YFLogxK
U2 - 10.1097/00042737-199306000-00013
DO - 10.1097/00042737-199306000-00013
M3 - Article
AN - SCOPUS:0027163919
SN - 0954-691X
VL - 5
SP - 467
EP - 469
JO - European Journal of Gastroenterology and Hepatology
JF - European Journal of Gastroenterology and Hepatology
IS - 6
ER -