Verapamil is beneficial in a model of post-ERCP pancreatitis

Austin L. Leahy, Ara Darzi, Pierce Grace, Akthar Qureshi, Paul Redmond, Mary Leader, David J. Bouchier-Hayes, Patrick Broe

Research output: Contribution to journalArticlepeer-review

Abstract

To assess the effect of the calcium blocking drug, verapamil, in an experimental model of acute pancreatitis. Acute pancreatitis was induced by retrograde taurocholate injection into the pancreato-biliary duct of Sprague-Dawley rats. The rats were then randomized into four groups and 1 ml saline or verapamil (1 g/kg) was administered before induction of pancreatitis or 2 h after taurocholate injection. Pancreatitis was confirmed by elevation of serum amylase levels and by histological alterations in pancreatic specimens from all animals. Survival was significantly increased in rats given verapamil prior to the induction of pancreatitis; however, delayed treatment was not effective. This study suggests that verapamil may have a beneficial role in the prophylaxis of pancreatitis following endoscopic retrograde cholangiopancreatography (ERCP).

Original languageEnglish
Pages (from-to)467-469
Number of pages3
JournalEuropean Journal of Gastroenterology and Hepatology
Volume5
Issue number6
DOIs
Publication statusPublished - Jun 1993
Externally publishedYes

Keywords

  • Acute pancreatitis
  • Calcium blockade
  • Endoscopic retrograde cholangiopanceatography
  • Verapamil

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