TY - JOUR
T1 - Vitamin D receptor genetic polymorphisms and the risk of multiple sclerosis
T2 - A systematic review and meta-analysis
AU - Mohammadi, Asadollah
AU - Azarnezhad, Asaad
AU - Khanbabaei, Hashem
AU - Izadpanah, Esmael
AU - Abdollahzadeh, Rasoul
AU - Barreto, George E.
AU - Sahebkar, Amirhossein
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/6
Y1 - 2020/6
N2 - There are conflicting results regarding the exact effect of the vitamin D receptor (VDR) gene polymorphisms on the susceptibility to multiple sclerosis (MS). Therefore, we aimed to investigate the impact of four major studied VDR gene polymorphisms consisting of ApaI, BsmI, FokI, and TaqI on the risk of MS in the Iranian population. A literature search was performed in various databases to find case-control studies evaluating the association between VDR gene polymorphisms and MS risk in Iran. Data were extracted and odds ratios (OR) with 95% confidence intervals (CI) were calculated. Subgroup analyze was performed to detect potential sources of heterogeneity. A total of 1206 cases and 1402 controls in nine case-control studies were included. ApaI was the only variant which showed statistically significant relation in allelic (OR = 0.54 (95% CI: 0.37–0.79); P = 0.00), homozygote (OR = 3.48 (95% CI: 1.7–6.9); P = 0.00), dominant (OR = 0.56 (95% CI: 0.3–0.79); P = 0.01), and recessive (OR = 0.35 (95% CI: 0.18–0.66); P = 0.00) models. The TaqI polymorphism showed a significant negative association with MS only in the homozygote model (OR = 0.28 (95% CI: 0.08–0.9); P = 0.04). The BsmI polymorphism also showed significant relation in allelic (OR = 0.69 (95% CI: 0.51–0.94); P = 0.01), homozygote (OR = 0.46 (95% CI: 0.25–0.86); P = 0.01), and recessive OR = 0.56 (95% CI: 0.39–0.8); P = 0.00) models after performing sensitivity analysis. FokI polymorphism showed no significant association with MS risk. ApaI and TaqI TT genotype were found contributing to MS susceptibility and BsmI and FokI showed no relation with MS susceptibility in the Iranian population.
AB - There are conflicting results regarding the exact effect of the vitamin D receptor (VDR) gene polymorphisms on the susceptibility to multiple sclerosis (MS). Therefore, we aimed to investigate the impact of four major studied VDR gene polymorphisms consisting of ApaI, BsmI, FokI, and TaqI on the risk of MS in the Iranian population. A literature search was performed in various databases to find case-control studies evaluating the association between VDR gene polymorphisms and MS risk in Iran. Data were extracted and odds ratios (OR) with 95% confidence intervals (CI) were calculated. Subgroup analyze was performed to detect potential sources of heterogeneity. A total of 1206 cases and 1402 controls in nine case-control studies were included. ApaI was the only variant which showed statistically significant relation in allelic (OR = 0.54 (95% CI: 0.37–0.79); P = 0.00), homozygote (OR = 3.48 (95% CI: 1.7–6.9); P = 0.00), dominant (OR = 0.56 (95% CI: 0.3–0.79); P = 0.01), and recessive (OR = 0.35 (95% CI: 0.18–0.66); P = 0.00) models. The TaqI polymorphism showed a significant negative association with MS only in the homozygote model (OR = 0.28 (95% CI: 0.08–0.9); P = 0.04). The BsmI polymorphism also showed significant relation in allelic (OR = 0.69 (95% CI: 0.51–0.94); P = 0.01), homozygote (OR = 0.46 (95% CI: 0.25–0.86); P = 0.01), and recessive OR = 0.56 (95% CI: 0.39–0.8); P = 0.00) models after performing sensitivity analysis. FokI polymorphism showed no significant association with MS risk. ApaI and TaqI TT genotype were found contributing to MS susceptibility and BsmI and FokI showed no relation with MS susceptibility in the Iranian population.
KW - Iranian population
KW - Meta-analysis
KW - Multiple sclerosis
KW - Vitamin D receptor
UR - http://www.scopus.com/inward/record.url?scp=85080046927&partnerID=8YFLogxK
U2 - 10.1016/j.steroids.2020.108615
DO - 10.1016/j.steroids.2020.108615
M3 - Review article
C2 - 32097613
AN - SCOPUS:85080046927
SN - 0039-128X
VL - 158
SP - -
JO - Steroids
JF - Steroids
M1 - 108615
ER -