Wood-Derived Hydrogels as a Platform for Drug-Release Systems

Mario Culebras; Anthony Barrett; Mahboubeh Pishnamazi; Gavin Michael Walker; Maurice N. Collins

doi:10.1021/acssuschemeng.0c08022

Wood-Derived Hydrogels as a Platform for Drug-Release Systems

Mario Culebras, Anthony Barrett, Mahboubeh Pishnamazi, Gavin Michael Walker, Maurice N. Collins

University of Limerick

Research output: Contribution to journal › Article › peer-review

Abstract

Wood (cellulose and lignin)-based hydrogels were successfully produced as platforms for drug-release systems. Viscoelastic and cross-linking behaviors of precursor solutions were tuned to produce highly porous hydrogel architectures via freeze-drying. Pore sizes in the range of 100-160 μm were obtained. Varying lignin molecular structure played a key role in tailoring swelling and mechanical performance of these gels with organosolv-type lignin showing optimum properties due to its propensity for intermolecular cross-linking, achieving a compressive modulus around 11 kPa. Paracetamol was selected as a standard drug for release tests and its release rate was improved with the presence of lignin (50% more compared to pure cellulose hydrogels). This was attributed to a reduction in molecular interactions between paracetamol and cellulose. These results highlight the potential for the valorization of lignin as a platform for drug-release systems.

Original language	English
Pages (from-to)	2515-2522
Number of pages	8
Journal	ACS Sustainable Chemistry and Engineering
Volume	9
Issue number	6
DOIs	https://doi.org/10.1021/acssuschemeng.0c08022
Publication status	Published - 15 Feb 2021

Keywords

cellulose
cross-linking
drug release
lignin
rheology

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10.1021/acssuschemeng.0c08022

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title = "Wood-Derived Hydrogels as a Platform for Drug-Release Systems",

abstract = "Wood (cellulose and lignin)-based hydrogels were successfully produced as platforms for drug-release systems. Viscoelastic and cross-linking behaviors of precursor solutions were tuned to produce highly porous hydrogel architectures via freeze-drying. Pore sizes in the range of 100-160 μm were obtained. Varying lignin molecular structure played a key role in tailoring swelling and mechanical performance of these gels with organosolv-type lignin showing optimum properties due to its propensity for intermolecular cross-linking, achieving a compressive modulus around 11 kPa. Paracetamol was selected as a standard drug for release tests and its release rate was improved with the presence of lignin (50% more compared to pure cellulose hydrogels). This was attributed to a reduction in molecular interactions between paracetamol and cellulose. These results highlight the potential for the valorization of lignin as a platform for drug-release systems.",

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AU - Culebras, Mario

AU - Barrett, Anthony

AU - Pishnamazi, Mahboubeh

AU - Walker, Gavin Michael

AU - Collins, Maurice N.

N1 - Publisher Copyright: ©

PY - 2021/2/15

Y1 - 2021/2/15

N2 - Wood (cellulose and lignin)-based hydrogels were successfully produced as platforms for drug-release systems. Viscoelastic and cross-linking behaviors of precursor solutions were tuned to produce highly porous hydrogel architectures via freeze-drying. Pore sizes in the range of 100-160 μm were obtained. Varying lignin molecular structure played a key role in tailoring swelling and mechanical performance of these gels with organosolv-type lignin showing optimum properties due to its propensity for intermolecular cross-linking, achieving a compressive modulus around 11 kPa. Paracetamol was selected as a standard drug for release tests and its release rate was improved with the presence of lignin (50% more compared to pure cellulose hydrogels). This was attributed to a reduction in molecular interactions between paracetamol and cellulose. These results highlight the potential for the valorization of lignin as a platform for drug-release systems.

AB - Wood (cellulose and lignin)-based hydrogels were successfully produced as platforms for drug-release systems. Viscoelastic and cross-linking behaviors of precursor solutions were tuned to produce highly porous hydrogel architectures via freeze-drying. Pore sizes in the range of 100-160 μm were obtained. Varying lignin molecular structure played a key role in tailoring swelling and mechanical performance of these gels with organosolv-type lignin showing optimum properties due to its propensity for intermolecular cross-linking, achieving a compressive modulus around 11 kPa. Paracetamol was selected as a standard drug for release tests and its release rate was improved with the presence of lignin (50% more compared to pure cellulose hydrogels). This was attributed to a reduction in molecular interactions between paracetamol and cellulose. These results highlight the potential for the valorization of lignin as a platform for drug-release systems.

KW - cellulose

KW - cross-linking

KW - drug release

KW - lignin

KW - rheology

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Wood-Derived Hydrogels as a Platform for Drug-Release Systems

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Keywords

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